Volume one of the Works of David Clarkson contains sermons on a wide variety of themes, including sin and repentance, the work of Christ, the nature of faith, prayer, living as strangers, bearing the cross and knowing Christ.

Volume two of Clarkson's Works contain a number of Clarkson's expositions on the depravity, inability and guilt of man, but also strikes a different note with his rich expositions on the new creature (Gal. 6.15), God's purposes in the afflictions of believers (Isa. 27.9), freedom from anxiety and prayer for all things (both on Phil. 4.6), as well as other biblical themes." This volume also includes "Soul Idolatry Excludes Men out of Heaven.

Volume three of the Works of David Clarkson contains several of Clarkson's finest sermons on the love, humanity, sacrifice and intercession of Jesus Christ, as well as his great polemical treatise Against the Practical Divinity of the Papists. Here he not only refutes the teaching of Rome, but also shows the importance of true knowledge and worship of God.